Blar i forfatter "Bhavsar, Swapnil"

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    • Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells 

      Bhavsar, Swapnil; Olsen, Lotte; Løkke, Cecilie; Koster, Jan; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Background: Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in ...

    • Metastasis in neuroblastoma: the MYCN question 

      Bhavsar, Swapnil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      Oncogenic drivers like MYCN in neuroblastoma subsets continues to present a significant challenge owing to its strong correlation with high-risk metastatic disease and poor prognosis. However, only a limited number of MYCN-regulatory proteins associated with tumor initiation and progression have been elucidated. In this minireview, I summarize the recent progress in understanding the functional role ...

    • Recent advances in the roles of exosomal microRNAs in neuroblastoma 

      Bhavsar, Swapnil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)
      Exosomal miRNAs (exo-miRs), universally found in biofluids, tissues, and/or conditioned medium of the cell cultures play a significant role in cell - cell communication, thus driving cancer progression and metastasis. Very few studies have explored the role of exo-miRs in the progression of children’s cancer - neuroblastoma. In this mini review, I briefly summarize the existing literature on the ...